师资队伍

蒋翠花

专业代码:105600

专业名称:中药学

学术/专业型:专业型

职务

  • 硕士生导师

—— 个人简介 ——

个人简介:

博士,副研究员,2011年毕业于中国药科大学中药学专业,并于当年就职于海燕策略研究线路一。主持及参与国家、省部级课题10余项,发表SC论文2 0余篇,授权专利8项,获得省、市级科学技术进步奖4项。


近五年主持在研课题:

[1]国家自然基金青年项目青钱柳三萜调控SIRT1/NF-κB信号通路干预肥胖2型糖尿病的效应及机制研究,815033162016.01-2018.1218万元,结题。

[2]院企合作项目,EACA-AB 抗肿瘤活性研究 H2021022021.05-2024.0620万元,主持;

[3]院企合作项目,祛疣洗剂医院制剂的研制-1 H202209-12022.12-2025.0220万元,主持;

[4]院企合作项目,昆山市中西医结合医院中药制剂临床验方备案研制,H20230052023.08-2025.0831万元,主持


授权专利:

[1]张健高萌蒋翠花王小宁张东建刘雪娇黄德健王琴放射性同位素标记的单蒽核蒽醌类化合物在制备用于检测心肌活性的药物中的应用,专利号:ZL 201410745394.3.授权日期2017.5.24

[2]张健孙自平吉云蒋翠花江骁方志军高萌李玥姚楠胆酸盐溶液在制备萘并二蒽酮类药物制剂中的应用,专利号:ZL201310111593.4. 授权日期2017.8.29

[3]张健孙自平高萌蒋翠花李玥江骁姚楠黄德建同位素标记的二蒽酮类化合物在制备肿瘤药物中的应用,专利号:ZL201310606546.7.授权日期2018.4.13

[4] 张健王聪蒋翠花高萌联二蒽醌类化合物在制备抗肿瘤药物中的应用,专利号:ZL201510491360.0.授权日期2018.12.28

[5]张健卞丽高萌金乔梅蒋翠花张东建联二蒽醌类化合物在制备抗肿瘤药物中的应用,专利号:ZL201610838325.6.授权日期2020.12.25 


其他成果

[1]张健,倪以成,蒋翠花,张东建,金乔梅,高萌,姚楠,蒽醌类分子探针用于坏死组织诊断和治疗,江苏省中医药协会,江苏省中医药科学技术奖,二等奖

[2]张健,张东建, 蒋翠花,高萌,倪以成,天然蒽醌类化合物坏死组织靶向性的发现及诊疗药物的设计,江苏省医学会,南京中医药科学技术奖, 二等奖

[3]张健,高萌,张东建,蒋翠花,金乔梅,蒽醌类坏死组织靶向性分子探针的构建及其诊疗潜力研究,南京中医药学会,江苏医学科技奖,三等奖, 2021 


联系方式:jiangshan806@163.com


擅长: 1.中药及天然药物防治糖尿病及并发症、肿瘤、痴呆心血管疾病等药效物质基础及作用机理研究 2.医院中药制剂临床验方备案研制 3.中药创新药物研制

—— 发表文章 ——

近五年发表文章:

[1] Chang-qian Fang1 Yuan Teng1 Yi-ting Wang Yuan-yuan Zhao Xian Zheng Lan Long Jian Zhang Ren-dong Zheng Xiao-long Cao* Cui-hua Jiang*. Arjunolic acid from Cyclocarya paliurus selectively inhibits glucagon secretion from α cells and ameliorates diabetes via ephrin-A1 and EphA4 interaction Journal of Functional Foods 202299(2022)105323

[2] Jingjing Cao1 Rendong Zheng1 Xiaoyan Chang Yuanyuan Zhao Dongjian Zhang Meng Gao Zhiqi Yind Cuihua Jiang* Jian Zhang*. Cyclocarya paliurus triterpenoids suppress hepatic gluconeogenesis via AMPK-mediated cAMP/PKA/CREB pathway Phytomedicine 2022 102(2022) 154175

[3] Cuihua Jiang# Jian Zhang# Shihe Hu Meng Gao Dongjian Zhang Nan Yao Qiaomei Jin* Target identification and occupancy measurement of necrosis avid agent rhein using bioorthogonal chemistry-enabling probes RSC Advances 2022 12 16491-16495.

[4] Dongjian Zhang #  Meng Gao #  Qiaomei Jin  Yicheng Ni  Huailiang Li  Cuihua Jiang* Jian Zhang * Development of Duramycin‑based Molecular Probes for Cell Death Imaging Molecular Imaging and Biology 2022 24(4) 612-629.

[5]Qiaomei Jin*# Cuihua Jiang# Meng Gao Dongjian Zhang Shihe Hu and Jian Zhang* Direct Cyclopropanation of Quinolinium Zwitterionic Thiolates via Dearomative Reactions J. Org. Chem. 2021 86 15640-15647.

[6] Cuihua Jiang Yiting Wang Qiaomei Jin Dongjian Zhang Meng Gao Nan Yao Zhiqi Yin Jian Zhang* Shiping Ma*. Cyclocarya paliurus triterpenoids improve diabetes-induced hepatic inflammation via the Rho-Kinase-dependent pathway Frontiers in Pharmacology 201910(811):1-13

[7] Cuihua Jiang# Rongling Zhong# Jian Zhang Xiangxiang Wang Gang Ding Wei Xiao Shiping Ma* Reduning injection ameliorates paraquat‐induced acute lung injury by regulating AMPK/MAPK/NF‐κB signaling Journal of Cellular Biochemistry 2018 120(8):12713-12723

[8] Xuanxuan Zhang# Cuihua Jiang# Yao Liu Dongxiao Lou Yaping Huang Meng Gao Jian Zhang* Zhiqi Yin* Ke Pan*. Cyclocarya paliurus triterpenic acids fraction attenuates kidney injury via AMPK-mTOR-regulated autophagy pathway in diabetic rats Phytomedicine 2019 64 153060

[9]Mengge Zhao Xueping Sheng Yaping Huang Yiting Wang Cuihua Jiang* Jian Zhang⁎ Zhi-qi Yin⁎ Triterpenic acids-enriched fraction from Cyclocarya paliurus attenuates nonalcoholic fatty liver disease via improving oxidative stress and mitochondrial dysfunction Biomedicine & Pharmacotherapy 2018 104(2018):229-239


—— 学术兼职 ——