师资队伍

李松林

专业代码:100800

专业名称:中药学

学术/专业型:学术型

职务

  • 博士生导师(科学学位)

—— 个人简介 ——

2000年毕业于中国药科大学,获理学博士学位。主持国家863计划和国家自然科学基金等国家和部省级课题20多项。发表论文200多篇,其中SCI收录120多篇,学术报告30多次。部分成果作为《Medicinal Research Reviews》和《药学学报》封面文章发表。建立的中药质量控制方法被列入国家法定标准。获授权专利4项,中药新药研究成果实施技术转让。副主编出版《生药学》、《中药分析学》、《现代生药学》和《中国藤黄属植物化学成分及生物活性研究》。是J Chromatogr A等多个国际专业期刊的特邀审稿人。曾获“南京军区优秀中青年科技人才”称号,获江苏省药学会中药质量专委会2018年度学术成就奖;中药质量控制研究成果获2018年江苏分析测试科学技术奖一等奖。

擅长: 以临床需求为导向,整合多组学手段,聚焦肠道菌群靶标,开展中药药效物质、作用机制、质量控制研究和健康产品研发,实现中医药的传承和创新转化。

—— 发表文章 ——

[1] Shan-Shan Zhou# Kathy Ka-Wai Auyeung# Ka-Man Yip Rong Ye Zhong-Zhen Zhao Qian Mao Jun Xu* Hu-Biao Chen* Song-Lin Li*. Stronger Anti-obesity Effect of White Ginseng over Red Ginseng and the Potential Mechanisms Involving Chemically Structural/Compositional Specificity to Gut Microbiota. Phytomedicine 2018 https://doi.org/10.1016/j.phymed.2018.11.021

[2] Li Zhou# Jin-Di Xu# Shan-Shan Zhou He Zhu Ming Kong Hong Shen Ye-Ting Zou Long-Jie Cong Jun Xu* Song-Lin Li*. Independent or integrative processing approach of metabolite datasets from different biospecimens potentially affects metabolic pathway recognition in metabolomics. Journal of Chromatography A 2019; 1587: 146–154

[3] Shan-Shan Zhou # Jia-Wei Hu # Ming Kong Jin-Di Xu Hong Shen Hu-Biao Chen Ming-Qin Shen * Jun Xu * Song-Lin Li *. Less SO2 residue may not indicate higher quality better efficacy and weaker toxicity of sulfur-fumigated herbs: Ginseng a pilot study. Journal of Hazardous Materials 2019; 364: 376-387.

[4] Jing Zhou # Jie Wu # Cheng-Ying Wu Fang Long Hong Shen Wei Zhang* Song-Lin Li*. Herb-drug interaction: A case study of effects and involved mechanisms of cisplatin on the pharmacokinetics of ginsenoside Rb1 in tumor-bearing mice. Biomedicine & Pharmacotherapy 2019; 110: 95-104.

[5] Xiu-Yang Li# Jin-Di Xu# Shan-Shan Zhou Ming Kong Ya-Yun Xu Ye-Ting Zou Ya Tang Li Zhou Ming-Zhe Xu Jun Xu* Song-Lin Li*. Time segment scanning-based quasi-MRM mode by UPLC-QTOF-MS/MS for quantitative determination of herbal medicines a case study on Mutan Cortex. Journal of Chromatography A 2018; 1581–1582 33-42.

[6] Ye-Ting Zou # Fang Long # Cheng-Ying Wu Jing Zhou Wei Zhang Jin-Di Xu Ye-Qing Zhang * Song-Lin Li*. Rapid and sensitive identification of triterpene acids from Poria by UPLC-QTOF-MS/MS with automatic analogue matching strategy. Phytochemcal analysis 2018 DOI: 10.1002/pca.2813

[7] 邹叶廷 徐金娣 龙 芳 张业清 李松林*. 整合UPLC-QTOF-MS/MS全扫描和模拟MRM方法综合评价茯苓乙醇提取物与后续乙酸乙酯萃取物三萜酸类组分化学一致性. 药学学报 2019;54(1): 130-137

[8] 刘婷,孔铭,刘丽芳*,李松林*. 黄芩药材商品规格与内在质量相关性研究.中国医药报2018; 46(4): 41-47.

[9] 伍城颖,周静,龙芳,张蔚,沈红,李松林*. 基于专利数据的我国魔芋资源产业化发展现状及趋势分析. 中药材2018; 41(4): 839-843

[10] Ya-Yun Xu # Fang Long # Ye-Qing Zhang Jin-Di Xu Ming Kong* Song-Lin Li*. Chemical markers for quality control of bran-fried sulfur-fumigatedPaeoniae Radix Alba. Journal of Pharmaceutical and Biomedical Analysis 2018; 159: 305-310.

[11] Cheng-Ying Wu # Ming Kong# Wei Zhang Fang Long Jing Zhou Shan-Shan Zhou Jin-Di Xu Jun Xu * Song-Lin Li*. Impacts of sulfur-fumigation on the chemistry of ginger. Food Chemistry 2018; 239: 953-963.

[12] Li Zhang # Hong Shen # Jun Xu Jin-Di Xu Zhen-Ling Li Jie Wu Ye-Ting Zou Li-Fang Liu* Song-Lin Li*. UPLC-QTOF-MS/MS-guided isolation and purification of sulfur-containing derivatives from sulfur-fumigated edible herbs a case study on ginseng. Food Chemistry 2018; 246: 202-210.

[13] Ming Kong# Huan-Huan Liu# Jie Wu Ming-Qin Shen Zhi-Gang Wang Su-Min Duan Yan-Bo Zhang He Zhu* Song-Lin Li*. Effects of sulfur-fumigation on the pharmacokinetics metabolites and analgesic activity of Radix Paeoniae Alba. Journal of Ethnopharmacology 2018: 212: 95-105.

[14] Hong Shen Xue-Jiao Gao Ting Li Wang-Hui Jing Bei-Lei Han Yu-Meng Jia Nan Hu Zhi-Xiang Yan Song-Lin Li* Ru Yan*. Ginseng polysaccharides enhanced ginsenoside Rb1 and microbial metabolites exposure through enhancing intestinal absorption and affecting gut microbial metabolism. Journal of Ethnopharmacology 2018; 216 : 47–56.

[15] 武洁,徐亚运,孔铭,李松林*. 硫熏当归配方颗粒的安全性检控指标分析. 中国实验方剂学杂志2018; 24: 20-24

[16] Li Zhou# Jin-Di Xu# Shan-Shan Zhou Hong Shen Qian Mao Ming Kong Ye-Ting Zou Ya-Yun Xu Jun Xu* Song-Lin Li*. Chemomics-based marker compounds mining and mimetic processing for exploring chemical mechanisms in traditional processing of herbal medicines a continuous study on Rehmanniae Radix. Journal of Chromatography A 2017; 1530: 232–240

[17] Shan-Shan Zhou# Jun Xu# Ming Kong Ka-Man Yip Jin-Di Xu Hong Shen Zhong-Zhen Zhao Song-Lin Li* Hu-Biao Chen**. Synchronous characterization of carbohydrates and ginsenosidesyields deeper insights into the processing chemistry of ginseng. Journal of Pharmaceutical and Biomedical Analysis 2017; 145: 59-70.

[18] Jun Xu Hu-Biao Chen * Song-Lin Li *. Understanding the molecular mechanisms of the interplay between herbal medicines and gut microbiota. Medicinal Research Reviews 2017; 37(5): 1140–1185.

[19] Qian Mao# Lei Shi# Zhi-Gang Wang Yu-Hui Luo Yin-Yu Wang Xue Li Min Lu Jian-Min Ju Jin-Di Xu Ming Kong Shan-Shan Zhou Min-Qin Shen* Song-Lin Li*. Chemical profiles and pharmacological activities of Chang-Kang-Fang a multi-herb Chinese medicinal formula for treating irritable bowel syndrome. Journal of Ethnopharmacology 2017; 201: 123-135

[20] 孔铭,徐亚运,李松林*.硫熏药材检控方法评述和创新研究策略探讨.药物分析杂志 2017;37(10): 1739-1746

[21] 徐亚运,孔 铭*,李松林**. 硫熏白芍配方颗粒检控指标的探讨.中草药2017; 48(18):3728-3733

[22] Xiu-Yang Li# Fang Long# Jin-Di Xu Hong Shen Ming Kong He Zhu Ye-Qing Zhang* Song-Lin Li*. Paeonifiorin sulfonate as a characteristic marker for specifically inspecting Chinese patent medicine Liu–Wei–Di–Huang–Wan contained sulfur–fumigated Moutan Cortex. Journal of Pharmaceutical and Biomedical Analysis 2017; 138: 283–288

[23] Ming Kong# Jun Xu# Huan-Huan Liu Jin-Di Xu Xiu-Yang Li Min Lu Chun-Ru Wang Hu-Biao Chen* Song-Lin Li*. Effects of boiling duration in processing of White Paeony Root on its overall quality evaluated by ultra-high performance liquid chromatography quadrupole/time-of-flight mass spectrometry based metabolomics analysis and high performance liquid chromatography quantification. Chinese Journal of Natural Medicines 2017; 15(1): 1-5

[24] Bin Ma# Winnie Lai Ting Kan# He Zhu Song-Lin Li* Ge Lin*. Sulfur fumigation reducing systemic exposure of ginsenosides and weakening immunomodulatory activity of ginseng. Journal of Ethnopharmacology 2017; 195: 222–230

[25] Zhuo Wang# Jian-Qun Liu# Jin-Di Xu He Zhu Ming Kong Guo-Hua Zhang Su-Min Duan Xiu-Yang Li Guangfu Li Li-Fang Liu* Song-Lin Li*. UPLC/ESI-QTOF-MS-based metabolomics survey on the toxicity of triptolide and detoxication of licorice. Chinese Journal of Natural Medicines 2017; 15(6): 0474-0480

[26] Qian Mao Jin-di Xu Ming Kong Hong Shen He Zhu Shan-Shan Zhou Song-Lin Li* LC-MS-based metabolomics in traditional Chinese medicines research: personal experiences. Chinese Herbal Medicines 2017; 9(1): 14-21

[27] Li Zhou# Jin-Di Xu# Shan-Shan Zhou Qian Mao Ming Kong Hong ShenXiu-Yang Li Su-Min DuanJun Xu* Song-Lin Li*. Integrating targeted glycomics and untargeted metabolomics toinvestigate the processing chemistry of herbal medicines a case studyon Rehmanniae Radix. Journal of Chromatography A 2016; 1472: 74–87.

[28] Shan-Shan ZhouΔ Jun XuΔ He Zhu Jie Wu Jin-Di Xu Ru Yan Xiu-Yang Li Huan-Huan Liu Su-Min Duan Zhuo Wang Hu-Biao Chen Hong Shen* Song-Lin Li* Gut microbiota-involved mechanisms in enhancing systemic exposure of ginsenosides by coexisting polysaccharides in ginseng decoction. Scientific Reports 2016; 6: 22474; doi: 10.1038/srep22474

[29] 胡佳伟,周姗姗 沈明勤*,李松林*. 硫熏对人参抗应激和免疫调节作用的影响. 南京中医大学学报2016; 33(3): 258-262

[30] 董河,沈红,张丽,刘丽芳*,李松林*. 关于中国药典淫羊藿药材定量指标的商榷. 中药材2016;39:2794-2797

[31] 张丽,沈红,董河,段素敏,李松林*,刘丽芳*. 硫磺熏蒸中药材化学成分转化研究. 中国医药报2017;45:103-107

[32] 刘建群,王卓,徐金娣,张国华,辛贵忠,李松林*,刘丽芳*. 甘草干预雷公藤内酯酮的代谢组学分析. 中国实验方剂学杂志2016; 22(19):52-57

[33] 周丽,徐金娣,毛茜,汤亚,李松林*.地黄加工炮制研究新进展及展望. 中药材2016;39(5):1184-1190

[34] 李秀杨 段素敏 刘欢欢 徐金娣 孔铭,刘红权李松林*. 特征含硫衍生物对硫熏牡丹皮检控的意义. 药学学报2016; 51 (6): 972 −978

[35] 段素敏,孔铭,张艳波,李秀杨,刘丽芳*,李松林*. 硫磺熏蒸当归二氧化硫残留与内在质量变化相关性研究. 中国实验方剂杂志2016;22:41-44

[36] 段素敏,孔铭,刘欢欢,李秀杨,刘丽芳**,李松林*. 当归药材热风-微波联合干燥方法研究. 中草药2016; 47(19):3415-3419

[37] 汤亚,沈红,武洁,徐金娣,李松林 *. 提取浓缩时间对琼玉膏品质的影响. 中草药2016; 47:1106-1111

[38] Wei Zhang Shi-Hui Qian Da-Wei Qian Song-Lin Li *. Screening of intestinal bacterial metabolites of platycodin D using ultra-performance liquid chromatography/quadrupole time-of-flight mass spectrometry. The American Journal of Chinese Medicine 2016; 44: 817-833

[39] Qian Mao Pin-Hu Zhang Jie Yang Jin-Di Xu Ming Kong Hong Shen He Zhu Min Bai Li Zhou Guang-Fu Li Qiang Wang* Song-Lin Li**. iTRAQ-based Proteomic Analysis of Ginsenoside F2 on Human Gastric Carcinoma Cells SGC7901. Evidence-based Complementary and Alternative Medicine 2016; dx.doi.org/10.1155/2016/2635483

[40] Xiu-Yang LiΔ Jin-Di XuΔ Jun Xu Ming Kong Shan-Shan Zhou Eric Brand Hu-Biao Chen Hong-Quan Liu* Song-Lin Li*. UPLC-QTOF-MS based metabolomics coupled with diagnostic ion exploration strategy for rapidly evaluating sulfur-fumigation caused holistic quality variation of medicinal herbs Moutan Cortex as an example. Analytical Methods 2016; 8: 1034 – 1043.

[41] Su-Min DuanΔ Jun XuΔ Ying-Jia Bai Ming Kong Huan-Huan Liu Xiu-Yang Li Qing-Shan Zhang Hu-Biao Chen Li-Fang Liu** Song-Lin Li*. Sulfur dioxide residue in sulfur-fumigated edible herbs: the fewer the safer? Food Chemistry 2016; 192: 119–124.

—— 学术兼职 ——

兼任世界中医药联合会中药饮片质量专业委员会及中药鉴定专业委员会常务理事、中药分析委员会委员,中华中医药学会中药分析及中药鉴定专业委员会委员,中国中药协会中药新技术专业委员会理事,江苏省药学会中药质量专业委员会副主任委员,江苏省分析测试协会理事,江苏省中医药学会中药饮片研究专业委员会委员。