转化医学实验室

研究室简介：
    转化医学实验室紧密联系临床科室，以临床问题为核心开展各项研究。实验室结合运用中药化学、药物化学、靶向给药、分子药物等技术，从中药及天然药物中寻找靶向分子，构建靶向药物及分子探针，开展实体瘤诊治一体化药物、糖尿病治疗药物、心梗诊断试剂的研究。研制出具有自主知识产权的小分子肿瘤坏死靶向放射性药物，及肿瘤近期疗效评价试剂，填补了国内外相关产品的空白，从而提升了研究院的创新转化能力。转化医学实验室现有科研人员7名，成立5年来，取得喜人的成绩。发表SCI论文六十余篇，申请专利十余项，获国家省级基金资助十余项项，获得了南京市科技进步奖一项。同时与国内外著名院校和企业建立了紧密的合作关系。

研究方向：
研究方向一：从天然药物中寻找小分子坏死靶向化合物，并研究其在肿瘤坏死靶向治疗和心肌活性评价等方面的应用，最近我们以双蒽醌构建肿瘤靶向放射性药物、以单蒽醌构建的磁共振分子探针用于肿瘤近期疗效评价的研究取得了积极的进展；

研究方向二：实验室还致力于中药及天然药物药效物质基础及相关分子机制的研究，对我国独有中药青钱柳治疗代谢疾病进行深入研究，同时进行青钱柳等相关产品的转化。代表性的研究结果如下图所示： 
 

图1 ¹³¹I-sennidin A 可较长时间地（A2: 4天；B2: 8天）浓聚在肿瘤

图2 ^99mTc(EDDA)-HYNIC-2C-rhein可对坏死心肌快速活体成像

图3 青钱柳可显著减少内脏脂质含量并可调控NF-κB和JNK信号通路改善肥胖小鼠脂肪炎症

近期发表的代表性论文
1.    Qi Luo Qiaomei Jin Chang Su Dongjian Zhang Cuihua Jiang Anne Folta Fish Yuanbo Feng Yicheng Ni Jian Zhang* Zhiqi Yin*. Radiolabeled rhein as small-molecule necrosis avid agents for imaging of necrotic myocardium. Analytical Chemistry. 2017; 89 (2): 1260-1266.

2.    Aiyan Ji Qiaomei Jin Dongjian Zhang Hua Zhu Chang Su Xinghua Duan Li Bian Ziping Sun Yicheng Ni Jian Zhang* Zhi Yang* Zhiqi Yin*. Novel 18F-Labeled 1-hydroxyanthraquinone derivatives for necrotic myocardium imaging. ACS Medicinal Chemistry Letters. 2017; 8 (2): 191–195.

3.    Qin Wang# Shengwei Yang Cuihua Jiang Jindian Li Cong Wang Linwei Chen# Qiaomei Jin Shaoli Song Yuanbo Feng Yicheng Ni Jian Zhang* Zhiqi Yin*. Discovery of radioiodinated monomeric anthraquinones as a novel class of necrosis avid agents for early imaging of necrotic myocardium. Scientific Reports. 2016; 6: 21341.

4.    Cong Wang Qiaomei Jin Shengwei Yang Dongjian Zhang Qin Wang Jindian Li Shaoli Song Ziping Sun Yicheng Ni Jian Zhang* Zhiqi Yin*. Synthesis and Evaluation of 131I-skyrin as a necrosis avid agent for potential targeted radionuclide therapy of solid tumors. Molecular Pharmaceutics. 2016; 13(1): 180-189.

5.    Jindian Li# Jian Zhang# Shengwei Yang Cuihua Jiang Dongjian Zhang Qiaomei Jin Qin Wang Cong Wang Yicheng Ni Zhiqi Yin* Shaoli Song*. Synthesis and preclinical evaluation of radioiodinated hypericin dicarboxylic acid as a necrosis avid agent in rat models of induced hepatic muscular and myocardial necroses. Molecular Pharmaceutics. 2016; 13(1): 232-40.

6.    Xuejiao Liu Cuihua Jiang Dongjian Zhang Meng Gao Fei Peng Dejian Huang Ziping Sun Yicheng Ni Jian Zhang* Zhiqi Yin* Tumor necrosis targeted radiotherapy of non-small cell lung cancer using radioiodinated protohypericin in a mouse model Oncotarget 2015 6(28): 26400-26410.

7.    Cuihua Jiang Qingqing Wang Nan Yao Yonglan Ma Zi Lin Zhengfeng Wu Ming Zhao Chuntao Che Xulan Shang Shengzuo Fang Yicheng Ni Jian Zhang* Zhiqi Yin* Cholesterol-lowering effects and potential mechanisms of different polar extracts from cyclocarya paliurus leave in hyperlipidemic mice Journal of Ethnopharmacology 2015 176(24): 17-26.

8.    Cuihua Jiang Nan Yao Qingqing Wang Jinghua Zhang Yan Sun Na Xiao Kang Liu Fang Huang Shengzuo Fang Xulan Shang Baolin Liu Yicheng Ni Zhiqi Yin* Jian Zhang* Cyclocarya paliurus extract modulates adipokine expression and improves insulin sensitivity by inhibition of inflammation in mice Journal of Ethnopharmacology 2014 153(2): 344-351.

Group members
Group leader 
倪以成  张健
Other staff
姚楠、李玥、蒋翠花、高萌、金乔梅、张东建
Graduate students
罗麒、吉爱艳、段兴华、苏畅、卞丽、梁佳佳、马琳、刘立超、操兰洁、赵梦鸽、盛雪萍

联系方式：52362116（2116）